药酒外敷治疗寒湿阻络型股骨头坏死临床研究

Clinical Study on External Application of Medicated Wine for Osteonecrosis Femoral Head of Type of Cold-dampness Blocking Collaterals

目的:观察药酒外敷治疗寒湿阻络型股骨头坏死(ONFH)的临床疗效。方法:将80例寒湿阻络型ONFH患者随机分为观察组与对照组,每组40例。对照组给予骨蚀再造丸口服,结合拄拐负重、功能锻炼及双下肢皮牵引治疗,观察组在对照组治疗基础上给予药酒外敷。对比2组临床疗效及治疗前后髋关节疼痛视觉模拟评分法(VAS)评分,观察不良反应发生情况。结果:2组临床疗效比较,差异无统计学意义(Z=-0.907,P=0.364> 0.05)。治疗前,2组VAS评分比较,差异无统计学意义(P>0.05)。治疗后,2组VAS评分均较治疗前降低,差异均有统计学意义(P <0.01);观察组VAS评分低于对照组,差异有统计学意义(P <0.01)。2组治疗期间血常规、肝肾功能均未见异常,观察组出现过敏反应1例。结论:药酒外敷治疗寒湿阻络型ONFH,能有效缓解局部疼痛。

Objective:To observe the clinical effect of external application of medicated wine for osteonecrosis of femoral head(ONFH)of type of cold-dampness blocking collaterals.Methods:Divided 80 cases of ONFH patients with type of cold-dampness blocking collaterals randomly into the observation group and the control group,40 cases in each group.The control group was given the oral administration of Gushi Zaizao pills combined with treatment of weight-bearing crutch,functional exercise and double lower limb skin traction,while the observation group was additionally given the external application of medicated wine.Compared the clinical effect and the scores of visual analog scale(VAS)of hip pain in the two groups before and after treatment,and observed the occurrence of adverse reactions.Results:There was no significant difference being found in the comparison of the clinical effect between the two groups(Z=-0.907,P=0.364>0.05).Before treatment,there was no significant difference being found in the comparison of the VAS scores between the two groups(P>0.05).After treatment,the VAS scores of the two groups were lower than those before treatment(P<0.01);the VAS scores in the observation group were lower than that in the control group(P<0.01).There were no abnormalities being found in blood routine and liver and kidney function during the treatment of the two groups;one case of allergic reaction was found in the observation group.Conclusion:The external application of medicated wine for ONFH of type of cold-dampness blocking collaterals can effectively relieve local pain.