摘要
目的:观察复方君子汤配合CHOPE方案治疗复发难治性非霍奇金淋巴瘤的临床疗效及对外周血免疫球蛋白和血清乳酸脱氢酶(LDH)、血管内皮细胞生长因子(VEGF)、糖类抗原125 (CA125)水平的影响。方法:选取86例复发难治性非霍奇金淋巴瘤患者为研究对象,按随机数字表法分成对照组与研究组,每组43例。对照组给予CHOPE方案治疗,研究组采用复方君子汤配合CHOPE方案治疗。比较2组临床疗效、外周血免疫球蛋白和血清LDH、VEGF、CA125水平,记录不良反应发生情况。结果:研究组治疗总有效率86.05%,对照组治疗总有效率60.47%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组IgA、IgG、IgM水平均较治疗前降低(P <0.05);研究组IgA、IgG、IgM水平均高于对照组(P <0.05)。治疗后,2组血清LDH、VEGF、CA125水平均较治疗前降低(P <0.05);研究组血清LDH、VEGF、CA125水平均低于对照组(P <0.05)。研究组白细胞减少、贫血、血小板减少、中性粒细胞减少、恶心呕吐、脱发、便秘发生率均低于对照组(P <0.05)。结论:复方君子汤配合CHOPE方案治疗复发难治性非霍奇金淋巴瘤临床疗效显著,可防止外周血免疫球蛋白水平急剧下降,下调血清LDH、VEGF、CA125水平,减少不良反应产生。
Objective:To observe the clinical effect of Fufang Junzi tang combined with CHOPE plan for relapsed and refractory non-Hodgkin’s lymphoma and its effect on levels of peripheral blood immunoglobulin,serum lactate dehydrogenase(LDH),vascular endothelial growth factor(VEGF)and carbohydrate antigen 125(CA125).Methods:Enrolled 86 cases of patients with relapsed and refractory non-Hodgkin’s lymphoma in the study and divided them into the control group and the study group according to the random number table,43 cases in each group.The control group was given CHOPE plan,and the study group was treated with Fufang Junzi tang combined with CHOPE plan.Compared the clinical effect as well as the levels of peripheral blood immunoglobulin and serum LDH,VEGF and CA125 between the two groups,and recorded the occurrence of adverse reactions.Results:The total effective rate was 86.05%in the study group and 60.47%in the control group,difference being significant(P<0.05).After treatment,the levels of IgA,IgG and IgM in the two groups were lower than those before treatment(P<0.05);the levels of IgA,IgG and IgM in the study group were higher than those in the control group(P<0.05).After treatment,the levels of serum LDH,VEGF and CA125 in the two groups were lower than those before treatment(P<0.05);the levels of serum LDH,VEGF and CA125 in the study group were lower than those in the control group(P<0.05).The incidence of leukopenia,anemia,thrombocytopenia,neutropenia,nausea and vomiting,alopecia and constipation in the study group was lower than that in the control group(P<0.05).Conclusion:The application of Fufang Junzi tang combined with CHOPE plan has obvious clinical effect in treating relapsed and refractory non-Hodgkin’s lymphoma.It can prevent the sharp decline of levels of peripheral blood immunoglobulin,down-regulate the levels of serum LDH,VEGF,CA125 and reduce adverse reactions.
出处
《新中医》
CAS
2019年第8期190-193,共4页
New Chinese Medicine
基金
河南省医学科技攻关计划项目(201603109)