苦碟子注射液联合尼麦角林胶囊治疗老年血管性痴呆临床研究

Clinical Study on Kudiezi Injection Combined with Nicergoline Capsules in the Treatment of Senile Vascular Dementia

目的:观察苦碟子注射液联合尼麦角林胶囊治疗老年血管性痴呆(VD)的临床疗效。方法:将符合纳入标准的52例患者随机分为2组各26例。对照组常规给予尼麦角林胶囊治疗,观察组在对照组治疗方案的基础上加用苦碟子注射液进行治疗。于治疗前后采用智能状态检查量表(MMSE)与日常生活能力量表(ADL)进行评价,并比较2组临床疗效。结果:治疗后,2组MMSE各项评分、总得分与ADL得分均较治疗前增加,但与对照组比较,观察组得分增加更多,差异均有统计学意义(P <0.01,P <0.05);且观察组治疗后总体疗效优于对照组,差异均有统计学意义(P <0.05)。结论:与单用尼麦角林胶囊相比较,联合苦碟子注射液治疗老年血管性痴呆,可更好地改善患者的记忆力、语言能力等思维认知功能与行为能力,更好地保护患者的神经功能。

Objective:To observe the clinical effect of the therapy of Kudiezi injection combined with nicergoline capsules in the treatment of vascular dementia(VD)in senile patients.Methods:A total of 52 cases of patients who met the inclusion criteria were randomly divided into two groups,26 cases in each group.The control group was routinely treated with nicergoline capsules,and the observation group was additionally treated with Kudiezi injection based on the treatment of the control group.Before and after treatment,the scores of Mini-Mental State Examination(MMSE)and Activity of Daily Living(ADL)Scale were evaluated and the clinical effect was compared in the two groups.Results:After treatment,each score of MMSE and the total scores as well as the ADL scores in the two groups were increased when compared with those before treatment,but the scores were increased more in the control group than in the observation group,differences being significant(P<0.01,P<0.05).After treatment,the total therapeutic effect in the observation group was better than that in the control group,differences being significant(P<0.05).Conclusion:Compared with simple nicergoline capsules,the therapy of Kudiezi injection combined with nicergoline capsules in the treatment of VD in senile patients,can better improve the memory,language and other cognitive and behavioral functions,and better protect the neurological function of them.