复方芪棱汤联合西药治疗短暂性脑缺血发作临床研究

Clinical Study on Fufang Qiling Tang Combined with Western Medicine For Transient Ischemic Attack

目的:观察复方芪棱汤联合西药治疗短暂性脑缺血发作(TIA)的临床疗效。方法:选取106例TIA患者,按随机数字表法分为对照组和观察组,每组53例。对照组给予阿司匹林肠溶片及银杏达莫注射液治疗,观察组在对照组用药基础上加服复方芪棱汤。对比2组临床疗效,观察2组治疗前后相关指标的变化。结果:总有效率观察组86.79%,对照组69.81%,2组比较,差异有统计学意义(P <0.05)。治疗后,观察组大血小板数(L-BPC)、血小板体积分布宽度(PDW)、平均血小板体积(MPV)较治疗前、对照组降低,血小板计数(BPC)较治疗前、对照组升高,差异均有统计学意义(P <0.05)。治疗后,观察组血小板三磷酸肌醇(IP3)、血栓烷(TX) B2、血小板活化因子(PAF)含量较治疗前、对照组降低,血小板环磷酸腺苷(c AMP)含量较治疗前、对照组升高,差异均有统计学意义(P <0.05)。治疗后,观察组血清髓鞘碱性蛋白(MBP)、S100β蛋白(S-100β)、神经元特异性烯醇化酶(NSE)及神经胶质纤维酸性蛋白(GFAP)含量较治疗前、对照组降低,差异均有统计学意义(P <0.05)。结论:复方芪棱汤联合西药治疗可改善TIA患者的血小板参数和相关因子,修复受损神经,疗效显著。

Objective:To observe the clinical therapeutic effect of Fufang Qiling tang combined with western medicine for transient ischemic attack(TIA).Methods:A total of 106 patients with TIA were selected and divided into the control group and the observation group according to the random number table method,53 cases in each group.The control group was treated with aspirin enteric-coated tablets and Ginkgo Leaf Extract and Dipyridamole Injection,and the observation group was treated with Fufang Qiling tang based on the treatment of the control group.The clinical effect of the two groups was compared,and the changes of relevant indicators before and after treatment in the two groups were observed.Results:The total effective rate was 86.79%in the observation group and 69.81%in the control group,the difference being significant(P<0.05).After treatment,levels of Large blood platelet count(L-BPC),platelet volume distribution width(PDW)and mean platelet volume(MPV)in the observation group were decreased when compared with those before treatment and those in the control group,while levels of blood platelet count(BPC)were increased,differences being significant(P<0.05).After treatment,levels of Inositol triphosphate(IP3),thromboxane(TX)B2 and platelet activating factor(PAF)in the observation group were decreased when compared with those before treatment and those in the control group,while the platelet cyclic adenosine phosphate(cAMP)level was increased,differences being significant(P<0.05).Levels of myelin basic protein(MBP),S-100β,neuron-specific enolase(NSE)and glial fiber acidic protein(GFAP)in the observation group were significantly decreased when compared with those before treatment and those in the control group,differences being significant(P<0.05).Conclusion:The therapy of Fufang Qiling tang combined with western medicine can significantly improve the platelet parameters and related factors in TIA patients,repair their damaged nerves,and has significant therapeutic effect.