银黄清肺胶囊辅助治疗支气管扩张急性加重期临床研究

Clinical Study on Yinhuang Qingfei Capsules for Bronchiectasis at Acute Exacerbation Stage

目的:观察银黄清肺胶囊辅助治疗支气管扩张急性加重期患者的临床疗效。方法:将86例支气管扩张急性加重期患者按随机数字表法分为对照组和观察组各43例。对照组给予常规西医治疗,观察组在对照组基础上给予银黄清肺胶囊口服。比较2组患者咳嗽咳痰、发热、肺部啰音以及肺部炎症病灶好转时间,检测第一秒最大呼气量(FEV1),FEV1/用力肺活量(FVC),分析2组患者临床疗效,测定血清中超敏C反应蛋白(hs-CRP)、血清淀粉样蛋白A (SAA)以及白细胞介素-6 (IL-6)水平。结果:观察组咳嗽咳痰、发热、肺部啰音、肺部炎症病灶消失时间均小于对照组(P <0.05)。治疗前,2组FEV1、FEV1/FVC水平比较,差异无统计学意义(P> 0.05)。治疗后,2组FEV1、FEV1/FVC水平较治疗前升高,且观察组高于对照组,差异均有统计学意义(P <0.05)。治疗前,2组血清hs-CRP、SAA和IL-6水平比较,差异无统计学意义(P> 0.05)。治疗后,2组血清hs-CRP、SAA和IL-6水平较治疗前降低,且观察组低于对照组,差异均有统计学意义(P <0.05)。观察组总有效率为95.35%,高于对照组的76.74%,差异有统计学意义(P <0.05)。结论:在常规西医治疗基础上采用银黄清肺胶囊辅助治疗支气管扩张急性加重期患者疗效确切,可明显缓解咳嗽、咳痰症状,改善肺功能,该作用可能与减轻气道炎症水平有关。

Objective:To observe the clinical effect of Yinhuang Qingfei capsules for bronchiectasis at acute exacerbation stage.Methods:A total of 86 cases of patients with bronchiectasis at acute exacerbation stage were divided into the control group and the observation according to the random number table method,43 cases in each group.The control group was treated with routine western medicine,and the observation group was additionally given the oral administration of Yinhuang Qingfei capsules based on the treatment of the control group.The improvement time of cough and expectoration,fever,rales and the inflammatory focus in the lung in the two groups was compared;the forced expiratory volume in one second(FEV1)and the ratio of FEV1 to forced vital capacity(FVC)were detected;the clinical effect in the two groups was analyzed;the levels of high-sensitivity C-reactive protein(hs-CRP),serum amyloid A(SAA)and interleukin-6(IL-6)in serum were measured.Results:The disappearance time of cough and expectoration,fever,rales and the inflammatory focus in the lung in the observation group was earlier than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of FEV1 and FEV1/FVC in the two groups(P>0.05);after treatment,the above levels in the two groups were increased when compared with those before treatment,and the levels in the observation group were higher than those in the control group,differences being significant(P<0.05).Before treatment,compared the levels of hs-CRP,SAA and IL-6 in serum in the two groups,there was no significance in the difference(P>0.05);after treatment,the above levels in the two groups were decreased when compared with those before treatment,and the levels in the observation group were lower than those in the control group,differences being significant(P<0.05).The total effective rate was 95.35%in the observation group,higher than that of 76.74%in the control group,the difference being significant(P<0.05).Conclusion:The adjuvant therapy of Yinhuang Qingfei capsules based on routine western medicine in treating bronchiectasis at acute exacerbation stage has significant curative effect,and can obviously relieve cough and expectoration,as well as improve the lung function,which may be related to its alleviation of the level of airway inflammation.