复方鲜竹沥液辅助治疗老年支气管扩张急性加重期痰热壅肺证临床研究

Clinical Study on Compound Xianzhuli Juice for Bronchiectasis with Phlegm-Heat Obstructing the Lung Syndrome at Acute Exacerbation Stage in Senile

目的:探讨复方鲜竹沥液辅助治疗老年支气管扩张急性加重期痰热壅肺证的疗效以及对白细胞介素(IL)-6和IL-8水平的影响。方法:将支气管扩张急性加重期患者70例,随机分为对照组和观察组各35例。对照组给予常规治疗。观察组在对照组基础上予复方鲜竹沥液治疗。2组连续治疗2周。比较2组痰热壅肺证症状评分、肺功能、临床疗效以及痰液中IL-6和IL-8。结果:治疗2周后,2组痰热壅肺证症状评分减少(P <0.01);观察组治疗2周后痰热壅肺证症状评分低于对照组(P <0.01)。治疗2周后,2组1秒最大呼气量(FEV)1、用力肺活量(FVC)显著升高(P <0.01)。观察组治疗2周后FEV1和FVC高于对照组(P <0.01)。治疗2周后,观察组的总有效率91.43%,高于对照组71.43%,2组比较,差异有统计学意义(P <0.05)。治疗2周后,2组患者痰液中IL-6和IL-8水平降低(P <0.01);观察组治疗2周后痰液中IL-6和IL-8水平低于对照组(P <0.01)。结论:在常规治疗基础上复方鲜竹沥液辅助治疗老年支气管扩张急性加重期痰热壅肺证的疗效明显,下调IL-6和IL-8水平可能是其作用机制之一。

Objective:To discuss the curative effect of compound Xianzhuli juice for bronchiectasis with phlegm-heat obstructing the lung syndrome at acute exacerbation stage in senile,and its effect on the levels of interleukin(IL)-6 and IL-8.Methods:A total of 70 cases of patients with bronchiectasis at acute exacerbation stage were randomly divided into the control group and the observation group,35 cases in each group.The control group was given routine treatment,and the observation group was additionally treated with compound Xianzhuli juice based on the treatment of the control group.Both groups were treated for two weeks.The symptom scores of phlegm-heat obstructing the lung syndrome,the lung function,clinical effect and the levels of IL-6 as well as IL-8 in sputum in the two groups were compared.Results:After treatment for two weeks,the symptom scores of phlegm-heat obstructing the lung syndrome in the two groups were decreased(P<0.01);the above score in the observation group was lower than that in the control group(P<0.01).After treatment for two weeks,the forced expiratory volume in one second(FEV1)and forced vital capacity(FVC)in the two groups were significantly increased(P<0.01),and the above indexes in the observation group were higher than those in the control group(P<0.01).After treatment for two weeks,the total effective rate was 91.43%in the observation group,higher than that of 71.43%in the control group,the difference being significant(P<0.05).After treatment for two weeks,the levels of IL-6 as well as IL-8 in sputum in the two groups were decreased(P<0.01);and the above levels in the observation group were lower than those in the control group(P<0.01).Conclusion:The adjuvant therapy of compound Xianzhuli juice based on routine treatment has obvious curative effect in treating bronchiectasis with phlegm-heat obstructing the lung syndrome at acute exacerbation stage in senile,and one of its mechanism may be the down-regulation of the levels of IL-6 as well as IL-8.