槐耳颗粒联合ω-3鱼油脂肪乳注射液对胃肠道肿瘤术后患者营养状况及免疫功能的影响

Effect of Huaier Granules Combined with ω-3 Fish Oil Fat Emulsion Injection on Nutritional Status and Immune Function of Patients with Gastrointestinal Tumors after Operation

目的:观察槐耳颗粒联合ω-3鱼油脂肪乳注射液对胃肠道肿瘤术后患者营养状况及免疫功能的影响。方法:选取148例胃肠道肿瘤术后患者,按随机数字表法分为对照组和观察组各74例。2组患者术后均给予常规肠外营养支持,对照组另给予ω-3鱼油脂肪乳注射液治疗,观察组在对照组基础上联合槐耳颗粒治疗。观察2组患者营养状况、免疫功能,尿乳果糖/甘露醇(L/M)、血清二胺氧化酶(DAO)变化及并发症发生情况。结果:治疗前,2组血清白蛋白(Alb)、前白蛋白(PAB)、转铁蛋白(TF)水平比较,差异均无统计学意义(P> 0.05)。治疗后,2组血清Alb、PAB、TF水平较治疗前降低(P <0.05),观察组患者血清Alb、PAB、TF水平高于对照组(P <0.05)。治疗前,2组血清CD3^+、CD4^+、CD8^+比例及CD4^+/CD8^+值比较,差异均无统计学意义(P> 0.05)。治疗后,2组血清CD3^+、CD4^+比例、CD4^+/CD8^+值较治疗前降低(P <0.05),CD8^+比例较治疗前升高(P <0.05);且观察组血清CD3^+、CD4^+比例、CD4^+/CD8^+值高于对照组(P <0.05),CD8^+比例低于对照组(P <0.05)。治疗前,2组患者尿L/M和血清DAO水平比较,差异无统计学意义(P> 0.05)。治疗后,2组患者尿L/M、血清DAO水平较治疗前升高(P <0.05),且观察组低于对照组(P <0.05)。观察组并发症发生率为1.35%,对照组为10.81%,2组比较,差异有统计学意义(P <0.05)。结论:槐耳颗粒联合ω-3鱼油脂肪乳注射液治疗胃肠道肿瘤术后患者,能够有效改善患者营养状况,提高免疫及胃肠功能,具有更显著疗效和更高安全性。

Objective:To observe the effects of Huaier granules combined withω-3 fish oil fat emulsion injection on nutritional status and immune function of patients with gastrointestinal tumors after operation.Methods:Divided 148 cases of postoperative patients with gastrointestinal tumors randomly into the control group and the observation group according to random number table,74 cases in each group.Both groups received routine parenteral nutrition support after operation.The control group was treated withω-3 fish oil fat emulsion injection,while the observation group was additionally treated with Huaier granules.Observed the changes of nutritional status,immunity,urine fructose/mannitol(L/M),serum diamine oxidase(DAO)and the occurrence of complications.Results:Before treatment,there were no significant differences being found in the comparison of the levels of serum albumin(Alb),prealbumin(PAB)and transferrin(TF)between the two groups(P>0.05).After treatment,the levels of serum Alb,PAB and TF in the two groups were lower than those before treatment(P<0.05);the levels of serum Alb,PAB and TF in the observation group were higher than those in the control group(P<0.05).Before treatment,there were no significant differences being found in the comparison of serum CD3^+,CD4^+,CD8^+proportions and CD4^+/CD8^+values between the two groups(P>0.05).After treatment,the serum CD3^+,CD4^+proportions and CD4^+/CD8^+values in the two groups were lower than those before treatment(P<0.05)and the CD8^+proportions were higher than those before treatment(P<0.05);the serum CD3^+,CD4^+proportions and CD4^+/CD8^+in the observation group were higher than those in the control group(P<0.05);and the CD8^+proportion was lower than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of urine L/M and serum DAO levels between the two groups(P>0.05).After treatment,the levels of urine L/M and serum DAO in the two groups were higher than those before treatment(P<0.05);the level in observation group was lower than that in the control group(P<0.05).The incidence of complications was 1.35%in the observation group and 10.81%in the control group,compared the two groups,difference being significant(P<0.05).Conclusion:The application of Huaier granules combined withω-3 fish oil fat emulsion injection for patients with gastrointestinal tumors after operation can effectively improve the nutritional status,immunity and gastrointestinal function of patients and has more significant efficacy and higher safety.