加味五虎汤联合阿奇霉素治疗痰热闭肺证小儿支原体肺炎临床研究

Clinical Study on Modified Wuhu Tang Combined with Azithromycin for Mycoplasma Pneumonia in Children with Syndrome of Phlegm-heat Obstructing the Lung

目的:观察加味五虎汤联合阿奇霉素治疗痰热闭肺证小儿支原体肺炎的临床疗效。方法:将122例患儿随机分为2组,每组61例。对照组采用阿奇霉素治疗,治疗组在对照组的基础治疗上加用加味五虎汤加减治疗,2组疗程均为14天。观察患者咳嗽、发热、喘促、肺部湿啰音和血常规复常时间,统计2组治疗前后痰热闭肺辨证候评分,并评价临床疗效。结果:2组临床疗效比较,经秩和检验,差异有统计学意义(P <0.05),治疗组疗效优于对照组。治疗组发热消退时间、血常规复常时间及咳嗽、喘促、肺部湿啰音消失时间均短于对照组,差异有统计学意义(P <0.05)。治疗后,2组患儿发热、咳嗽、咯痰、气急、肺部啰音、口渴等痰热闭肺证候评分均较治疗前降低(P <0.05),且治疗组各项评分均低于对照组(P <0.05)。结论:加味五虎汤联合阿奇霉素治疗痰热闭肺证小儿肺炎支原体肺炎可有效缩短病程,改善症状,疗效优于单纯西药治疗。

Objective:To observe the clinical effect of modified Wuhu tang combined with azithromycin for mycoplasma pneumonia in children with syndrome of phlegm-heat obstructing the lung.%Methods:Divided 122 cases of children into two groups randomly,with 61 cases in each group.Both groups were treated with azithromycin and the treatment group was additionally treated with modified Wuhu tang.The course of treatment in both groups was 14 days.Observed the recovery time of cough,fever,asthma,lung moist rales and blood routine,recorded the syndrome differentiation scores of the syndrome of phlegm-heat obstructing the lung before and after treatment in the two groups,and evaluated the clinical effect.%Results:There was significant difference being found in the comparison of the clinical effect in the two groups by the rank sum test(P<0.05)and the efficacy in the treatment group was better than that in the control group.The extinction time of fever,the recovery time of blood routine and the disappearance time of cough,asthma,lung moist rales in the treatment group were shorter than those in the control group,difference being significant(P<0.05).After treatment,the scores of fever,cough,expectoration,breathlessness,pulmonary rales,thirst in the syndrome of phlegm-heat obstructing the lung in the two groups were all lower than those before treatment(P<0.05)and all the scores in the treatment group were lower than those in the control group(P<0.05).Conclusion:The application of modified Wuhu tang combined with azithromycin for mycoplasma pneumonia in children with the syndrome of obstruction of phlegm-heat obstructing the lung can effectively shorten the course and improve the symptoms,its efficacy being better than that of simple use of western medicine.