香砂养胃片结合四联疗法治疗Hp感染消化性溃疡肝气犯胃证临床研究

Clinical Study on Xiangsha Yangwei Tablets Combined with Quadruple Therapy in Treating Hp-Infected Peptic Ulcer with Syndrome of Liver Qi Attacking Stomach

目的:探讨香砂养胃片结合四联疗法治疗幽门螺杆菌(Hp)感染消化性溃疡肝气犯胃证的疗效以及对血清白细胞介素(IL)-6、IL-8水平的影响。方法:将76例Hp阳性的消化性溃疡患者按数字表法随机分为对照组和治疗组各38例。对照组采用标准四联疗法。治疗组在对照组基础上给予香砂养胃片。2组疗程均4周。比较2组肝气犯胃证症状评分、Hp根除率、临床疗效以及2组血清IL-6和IL-8水平。结果:治疗后,2组肝气犯胃证症状评分降低,且治疗组肝气犯胃证症状评分低于对照组,差异有统计学意义(P <0.01)。治疗4周后,治疗组患者的根除率为86.84%,高于对照组的65.79%,差异有统计学意义(χ~2=4.659,P=0.031 <0.05)。治疗组总有效率94.74%,高于对照组的76.32%(P <0.05)。治疗后,2组血清IL-6、IL-8水平减少,且治疗组血清IL-6、IL-8水平低于对照组(P <0.01)。结论:香砂养胃片结合四联疗法治疗Hp感染消化性溃疡肝气犯胃证的疗效明显,考虑与调节血清IL-6、IL-8水平有关。

Objective:To investigate the therapeutic effect of the therapy of Xiangsha Yangwei tablets combined with quadruple therapy in treating helicobacter pylori(Hp)infected peptic ulcer with syndrome of liver qi attacking stomach and its effect on levels of interleukin-6(IL-6)and interleukin-8(IL-8)in serum.%Methods:A total of 76 patients with Hp-positive peptic ulcer were randomly divided into the control group and the treatment group according to random number table method.The control group adopted standard quadruple therapy;the treatment group was additionally given Xiangsha Yangwei tablets based on the treatment of the control group.The course of treatment was four weeks in both groups.The symptom scores of syndrome of liver qi attacking stomach,Hp eradication rate,clinical effect and levels of IL-6 and IL-8 in serum of the two groups were compared.%Results:After treatment,the symptom scores of syndrome of liver qi attacking stomach in the two groups were decreased,and the scores in the treatment group were lower than those in the control group,the difference being statistically significant(P<0.01).After four weeks of treatment,the eradication rate in the treatment group was 86.84%,which was higher than that of 65.79%in the control group,the difference being statistically significant(χ~2=4.659,P=0.031<0.05).The total effective rate was 94.74%in the treatment group,higher than that of 76.32%in the control group(P<0.05).After treatment,levels of IL-6 and IL-8 in serum in the two groups were decreased,and the levels in the treatment group were lower than those in the control group(P<0.01).Conclusion:The therapy of Xiangsha Yangwei tablets combined with quadruple therapy has obvious therapeutic effect in treating Hp-infected peptic ulcer with syndrome of liver qi attacking stomach,which may be related to the regulation of levels of IL-6 and IL-8 in serum.