黄芪注射液对乳腺癌患者辅助化疗后胃肠道不良反应及营养状态的影响

Effect of Astragalus Injection in Assisting Post-chemotherapy Gastrointestinal Side Effects and Nutritional Status in Patients with Breast Cancer

目的:探究黄芪注射液对乳腺癌患者辅助化疗后胃肠道不良反应和营养状态的影响。方法:将化疗后乳腺癌患者83例按随机数字表法分为2组,对照组41例在化疗的基础上予以安慰剂进行辅助治疗,观察组42例在化疗的基础上予以黄芪注射液进行辅助治疗。对比2组患者治疗后胃肠道不良反应、毒性反应和生活质量以及治疗前后的营养状态的变化情况。结果:对照组不良反应率为36.59%,观察组为9.52%,2组比较,差异有统计学意义(P <0.05)。经治疗,2组白细胞(WBC)比较,差异无统计学意义(P> 0.05)。2组血红蛋白(Hb)、血小板计数(BPC)比较,差异有统计学意义(P <0.05)。观察组治疗后肱三头肌褶厚度、腰围、体质量优于对照组,差异有统计学意义(P <0.05)。观察组精神健康、情感功能、生理功能、心理状态、活动能力、躯体疼痛、社会功能、整体健康评分明显优于对照组,差异有统计学意义(P <0.05)。结论:黄芪注射液对乳腺癌患者辅助化疗后,可以有效减少患者胃肠道不良反应和毒性反应,维持患者的营养状态,提高生活质量。

Objective:To explore the effect of astragalus injection in assisting post-chemotherapy gastrointestinal side effects and nutritional status in patients with breast cancer.Methods:Divided 83 cases of post-chemotherapy patients with breast cancer into two groups randomly,41 cases in the control group and 42 cases in the observation group.The control group received pIacebo based on chemotherapy,while the observation group received astragalus injection based on chemotherapy.Compared the changes in gastrointestinal side effects,toxic reactions and quality of life after treatment as well as nutritional status before and after treatment of patients in both groups.Results:The incidence of adverse reactions was 36.59%in the control group and9.52%in the observation group,difference being significant(P<0.05).After treatment,comparing WBC in both groups,there was no significant difference being found(P>0.05).Comparing Hb and BPC in both groups,there was significant difference being found(P<0.05).After treatment,the skinfold thickness of triceps,waist circumference,body m ass in the observation group were better than those in the control group,difference being significant(P<0.05).The scores of mental health,emotional function,physiological function,mental state,activity ability,bodily pain,social function and ove rall health in the observation group were significantly better than those in the control group,difference being significant(P<0.05).Conclusion:Astragalus injection in assisting chemotherapy for breast cancer can effectively reduce gastrointestinal side effects and toxic reactions of patients,sustain their nutritional status and promote the quality of life.