系统性红斑狼疮合并急性冠状动脉综合征4例报道及文献复习

Systemic lupus erythematosus coexistent with acute coronary syndrome, a report of four cases with review of literature

目的 探讨系统性红斑狼疮 (SLE)累及患者冠状动脉的流行病学、病理生理学及临床特点。方法 收集分析 4例SLE合并急性冠状动脉综合征 (ACS)患者的临床和实验室资料并复习相关文献。结果 绝经期前女性SLE患者中ACS发病率明显增高。ACS是病程长的SLE患者的重要合并症。动脉粥样硬化和血栓形成是累及冠状动脉的最主要原因 ,冠状动脉血管炎及其他与SLE活动有关的因素则较为少见。结论 SLE患者存在早发ACS ,冠状动脉病 (CAD)

Objective To appraise the epidemiology, pathophysiology,clinical features and treatment of coronary artery disease in systemic lupus erythematosus. Methods 4 cases of acute coronary syndrome (ACS) in systemic lupus erythematosus patients were presented, together with the etiology and management reviewed. Results The incidence of acute coronary syndrome in premenopausal patients with SLE was significantly increased. ACS is an important complication of prolonged SLE. Atherosclerosis and thrombosis were accounted for the vast majority of coronary arterial diseases, but vasculitis of the coronary arteries and other factors related to active SLE were comparatively rare. Conclusion ACS may appear early in SLE patients and the coronary artery disease may be correlated with long course of the illness and long term use of prednisone.