摘要
根据单环 β-内酰胺类化合物定量构效关系研究的结果提示 ,以 N-苄基 - 3(S) -邻苯二甲酰亚胺基- 4 (S) - [4 (S) - 2 ,2 -二甲基 - 1,3二氧环戊 - 4 -基 ]- 2 -氧吖丁啶为原料 ,设计合成了 11个新的单环 β-内酰胺类化合物 ,其结构经 MS、1 H- NMR或 IR所确证 ,并测定了它们的体外抗菌活性 ,结果表明 ,它们均有抗菌作用 ,但抗菌活性低于对照品。
Based on the result of quantitative structure activity relationship (QSAR) which was studied among monobactams, 11 new monobactams were designed and synthesized from N-benzyl-3(S)-phthalimido-4(S)-[4(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-oxo-azetidine, their structure had been determined by 1H-NMR or IR and MS, and in vitroantibacterial activities of these compounds were tested. Results showed that they have lower activities than those of control compounds.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2003年第8期459-462,共4页
Chinese Journal of Antibiotics