加替沙星治疗呼吸系统和泌尿系统感染有效性和安全性的临床观察

Clinical efficacy and safety of gatifloxacin in the treatment of respiratory and urinary systems infection

目的 采用随机双盲平行对照方法观察加替沙星治疗呼吸系统感染和泌尿系统感染的疗效及不良反应。方法 以左氧氟沙星注射液为对照药 ,在 2 19例受试患者中进行双模拟双盲、随机平行对照试验。试验组 110例 ,给予加替沙星注射液 0 .4 g,静脉滴注 ,每天 1次 ;对照组 10 9例 ,给予左氧氟沙星注射液 0 .2 g,静脉滴注 ,每天 2次。疗程 7～ 14 d。观察疗效及不良反应。结果 试验组和对照组的临床有效率分别为95 .4 5 %和 93.5 7% (P>0 .0 5 ) ,细菌清除率分别为 92 .71%和 90 .0 0 % (P>0 .0 5 ) ,不良反应发生率分别为8.18%和 14 .6 8% ,两组间的差别无显著性意义。结论 加替沙星注射液是治疗呼吸道感染和泌尿系统感染安全有效的药物。

Objective To evaluate the efficacy and safety of gatifloxacin in the treatment of respiratory and urinary systems infection. Methods A double-blinded, double-modelling, randomized-controlled clinical trial was conducted. A total of 219 patients were enrolled (110 in trial group, 109 in control group). The trial group patients were given gatifloxacin 0.4g, iv, once a day for 7～14 days and the control group patients were given levofloxacin 0.2g, iv, twice a day for 7～14 days. Results Clinical effective rate was 95.45% in trial group and 93.57% in control group at the end of treatment (P>0.05); the bacterial clearance rate were 92.71% and 90.00% respectively (P>0.05); adverse reaction rates were 8.18% and 14.68% respectively (P>0.05). There were no statistic significance between the two groups. Conclusion Result suggested the gatifloxacin was an effective and safety antibacterial in the treatment of respiratory and urinary systems infection.