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细菌DNA激活免疫细胞的分子机制 被引量：4

Molecular mechanism of immune cells activated by bacterial DNA
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摘要 Bacterial DNA taken up by immune cells in a CpG motif-independent manner is translocated into endosome. Endosomal maturation is essential for subsequent bacterial DNA-mediated signal transduction. TLR9 is recruited into endosome to recognize bacterial DNA and initiate the TLR/IL-1R signal transduction pathway. As a result , transcription factors NF-κB and AP-1 are activated, which, in turn, leads to proinflammatory cytokine expression and induces a strong acute Th1-like inflammatory response. Bacterial DNA taken up by immune cells in a CpG motif-independent manner is translocated into endosome. Endosomal maturation is essential for subsequent bacterial DNA-mediated signal transduction. TLR9 is recruited into endosome to recognize bacterial DNA and initiate the TLR/IL-1R signal transduction pathway. As a result , transcription factors NF-κB and AP-1 are activated, which, in turn, leads to proinflammatory cytokine expression and induces a strong acute Th1-like inflammatory response.
作者 王良喜 周红
机构地区 第三军医大学药理学教研室
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2003年第8期1129-1132,共4页 Chinese Journal of Pathophysiology
基金 国家自然科学基金资助项目 (No .30 0 70 2 99)
关键词 DNA 细菌 免疫 细胞 内体 信号转导 炎症 DNA, bacterial Immunity, cellular Endosomes Signal transduction Inflammation
分类号 R363 [医药卫生—病理学]
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参考文献27

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二级参考文献7

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二级引证文献8

中国病理生理杂志
2003年 第8期

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