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骨髓增生异常综合征中的微环境异常 被引量：1

The abnormalities of microenvironment in myelodysplastic syndrome
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摘要 Myelodysplastic syndrome (MDS) is considered as a preleukemic course, characteristic of hypercellular marrow and pancytopenia. Many studies have demonstrated that defects occur in the heamtopoietic cells from patients with MDS. Recently, many abnormal changes in apoptosis, proliferation, ability of hematopoietic support, cytokine secretion, clonal origin of stromal cells and angiogenesis have also been revealed in the bone marrow microenvironment of MDS patients. Myelodysplastic syndrome (MDS) is considered as a preleukemic course, characteristic of hypercellular marrow and pancytopenia. Many studies have demonstrated that defects occur in the heamtopoietic cells from patients with MDS. Recently, many abnormal changes in apoptosis, proliferation, ability of hematopoietic support, cytokine secretion, clonal origin of stromal cells and angiogenesis have also been revealed in the bone marrow microenvironment of MDS patients.
作者 钱军 陈子兴
机构地区 苏州大学附属第一医院白血病研究室
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2003年第8期1137-1140,共4页 Chinese Journal of Pathophysiology
关键词 骨髓发育不良综合征 暾环境 细胞凋亡 新生血管化 Myelodysplastic syndromes Microenvironment Apoptosis Neovascularization
分类号 R363 [医药卫生—病理学]
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参考文献21

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同被引文献16

  • 1Klaus M,Stavroulaki E,Kastrinaki MC. Reserves,functional,immunoregulatory,and cytogenetic properties of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes[J].Stem Cells and Development,2010,(07):1043-1054.
  • 2Flores-Figueroa E,Montesinos JJ,Flores-Guzmán P. Functional analysis of myelodysplastic syndromes-derived mesenchymal stem cells[J].Leukemia Research,2008,(09):1407-4116.
  • 3Zhao ZG,Xu W,Yu HP. Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes[J].Cancer Letters,2011,(02):136-143.
  • 4Flores-Figueroa E,Arana-Trejo RM,Gutiérrez-Espíndola G. Mesenchymal stem cells in myelodysplastic syndromes:phenotypic and cytogenetic characterization[J].Leukemia Research,2005,(02):215-224.
  • 5Aanei CM,Flandrin P,Eloae FZ. Intrinsic growth deficiencies of mesenchymal stromal cells in myelodysplastic syndromes[J].Stem Cells and Development,2011.
  • 6Della Porta MG. Myelodysplastic syndromes and bone marrow microenvironment[J].Leukemia Research,2011,(11):1442-1443.
  • 7Ishibashi M,Tamura H,Ogata K. Disease progression mechanism in myelodysplastic syndromes:insight into the role of the microenvironment[J].Leukemia Research,2011,(11):1449-1452.
  • 8Davids MS,Steensma DP. The molecular pathogenesis of myelodysplastic syndromes[J].Cancer Biology and Therapy,2010,(04):309-319.
  • 9Zhang Y,Zhao H,Zhao D. SDF-1/CXCR4 axis in myelodysplastic syndromes:correlation with angiogenesis and apoptosis[J].Leukemia Research,2012,(03):281-288.
  • 10Catenacci DV,Schiller GJ. Myelodysplasic syndromes:a comprehensive review[J].Blood Reviews,2005,(06):301-319.

引证文献1

中国病理生理杂志
2003年 第8期

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