慢性HBV感染者红细胞C3b受体活性与抗病毒治疗应答临床研究

A Clinical Study on the Activity of Erythrocyte C3b Receptor in Patients with Chronic HBV Infection and Response to the antiviral Therapy

为探讨慢性HBV感染红细胞免疫(RCIA)机制及其与抗病毒治疗应答的关系,应用基因工程α-2bIFN联合天然药物对52例慢性HBV感染患者进行治疗,另以39例未经上述治疗患者作对照。在治疗前后并随访一年观察两组HBVM变化情况,同时应用补体致敏酵母菌花环法测定红细胞C3b受体活性及免疫复合物粘附程度并与正常对照。结果显示:慢性HBV感染有显著异常的RCIA改变,IFN联合疗法可使患者HBVM阴转率明显提高,但对RCIA持续低下者的疗效明显欠佳,一年后重复测定结果相同。研究提示:RCIA功能紊乱参与了慢性HBV感染的免疫病理过程,改善RCIA功能有利于调整患者对抗HBV治疗的免疫应答。

Objective In order to explore the mechanism of the red cell immune adherent (RCIA) function in the patients with chromic HBV infection and the correlation between their RCIA function and the response to antiviral therapy,α - 2bIFN combined with natural medicines were performed in 52 patients compared with 39 controls. Atsame time, we investigated the changes of HBV marker (HBVM) in the aforesaid groups prior to and at termination of treatments. The activity of RBC C3b receptor and immune complex resette were determined by yeast rosette test.Results showed significant higher rate of HBVM negative conversion in the group of received IFN combine therapy. Significant disorders of RCIA were observed in the patients with chronic HBV infection, The activity of RBC - C3bR in 29 patients not responsed to IFN combine therapy was distinct lower than those in 23 responders and same result was aquired in the period of following one year. Conclusion RCIA function disturbance was involved in immunopathy proscess of chronic HBV infection and improved RCIA function in the patients may be benefical to their immune response to the antiviral therapy.