原发性胃肠道恶性淋巴瘤45例分析

Clinical Analysis of 45 Patients with Primary Gastrointestinal Lymphomas

目的 :探讨原发性胃肠道淋巴瘤的诊治。 方法 :回顾性分析 4 5例胃肠道淋巴瘤病例。 结果 :4 5例中胃淋巴瘤32例 ,小肠淋巴瘤 5例 ,结肠淋巴瘤 5例 ,直肠淋巴瘤 3例。粘膜相关淋巴组织淋巴瘤 (MALTlymphomas)占 4 0 %。肿瘤浸润深度、淋巴结转移及是否为MALT淋巴瘤均与恶性程度相关 (P <0 0 5 )。低度、高度恶性者 5年生存率分别为 6 0 %和 36 %。 结论 :MALT淋巴瘤是最常见的病理类型。肿瘤的恶性程度是重要的预后因素。

Objective To investigate the diagnosis and treatment of primary gastrointestinal lymphomas(PGIL) Methods Forty-five cases of PGIL were retrospectively studied.Results The most common primary site of lymphomas was the stomach (32 cases),other sites included the small intestine(5 cases),the colon (5 cases)and the rectum(3 cases ).The mucosa-associated lymphoid tissue(MALT) lymphomas accounted for 40% of the total series.The depth of infiltration,lymph node lesion and MALT lymphomas involvement were correlated with the malignancy of PGIL significantly ( P <0.05).The 5-year survival rated for low-grade and high-grade lymphoma were 60% and 36% respectively. Conclusion WALT lymphomas are the largest histologic subtype seen.The malignancy of the tumor is one of the important prognostic factors.