非典型肺炎病人免疫功能分析

Analysis of Immunological Function for Patients with Severe Acute Respiratory Syndrome

目的 :动态监测非典型肺炎 (SARS)病人免疫功能 ,为临床诊疗提供帮助。方法 :采用回顾性及随访研究方法 ,对本院收治 10 3例SARS病人分别在入院初期、中期、高峰期、恢复期和随访时作C反应蛋白 (CRP)、免疫球蛋白、补体、纤维蛋白原 (Fib)、血沉 (ESR)、和CD4、CD8等免疫功能检查 ,并进行描述性分析及方差分析。结果 :从发病初期至恢复期CRP、Fib、ESR均有程度不同的升高 ,以CRP异常率最高。总蛋白、白蛋白、白蛋白 /球蛋白比值在疾病过程呈下降趋势。在SARS疾病过程中和随访时存在免疫球蛋白变化、补体消耗和CD4、CD8细胞减少。结论 :SARS病人免疫功能可能低于正常人。

Objective: Dynamic observation immunological function of patients with Severe Acute Respiratory Syndrome(SARS) and service clinical treatment of SARS.Method: Immunological function analysis such as CRP,IgG,IgA,IgM,C3,C4,Fib,ESR,CD4,CD8 were determined in 103 SARS patients during the first,middle,high,peak,recovery and follow up stage. The statistics of results was done.Results: There exited high concentration of CRP,Fib,ESR from first stage to recovery stage,respectively.The results of TP,Alb,A/G was in an decreasing tendency,respectively.There exited immunoglogical change,complement consumption and CD4,CD8 cell reduction during different stage of SARS.Conclusion: The function of cell mediated immunity and humoral immunity of SARS patients exited dynamic change and mar reduce more significant than that of health people.The results of Lab may help diagnosis and effect judgement.