混合性结缔组织病的神经系统合并症和肌症状、肌病理特点

Neurological complications in mixed connective tissue disease

对4例MCTD的神经系统合并症和肌症状,肌病理特点进行了初步探讨。认为MCTD的神经系统合并症从中枢神经至末梢神经呈现出多样的临床表现。MCTD的肌症状以四肢远端为著。肌活检发现轻度的肌纤维坏死和肌束膜、肌内膜的单核细胞漫润。其中2例出现了小角化纤维和群集萎缩。以上病理变化可能与合并末梢神经损伤有关。

Four patients with MCTD are reported. They had various neurological complications, trigeminal neuropathy, meningitis, cerebral infarction and polyneuropathy respectively. The clinicopatho logical features of myositis in MCTD are not clearly differentiated from pure polymyositis (PM), however, the muscle in MCTD tends to show more inflamatory infiltration at perimysiun than PM, whereas, PM shows more fiber necrosis. Neuropathic changes are frequently seen by EMG and muscle biopsy in MCTD. The pharyngeal and respiratory muscles are more frequently affected in PM and shows higher CK level at acute stage.