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采用组织芯片技术研究乳腺癌中p27和cyclinE的表达 被引量：2

By using tissue chip technique to study the expression of p27 and cyclinE in breast carcinoma
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摘要 Objective To study the expressions of p27,cyclinE and analysis it s meaning in breast carcinoma.Methods By using tissue chip tech-nique creating80c ases breast carcinoma tissue chip.at the same time using the S-P immunohis-to chemical methods,the expressions of p27and cy-clinE in breast carcinoma tissue chip was studied.Results The positive rates of p27and cyclinE were38.8%and52.5%i n80cases breast carcino-ma respectively.A significant correlation was found be tween the lowexpression of p27,overexpression of cyclinE and metastasis of lymph node in breast carcinoma.A significant correlation was found be-tween the lowe xpression of p27and overexpression of cyclinE in breast carcinoma.Conclusion The expression of p27and cyclinE might be considered to be a reference indicator f or prognosis of breast carcinoma.The lowexpression of p27has an ability to effec t the overexpression of cyclinE in breast carcinoma.It is feasible to utilize ti ssue chip for a rapid,economic and accurate screening of clinical tissue specime ns on a large scale. Objective To study the expressions of p27,cyclinE and analysis it s meaning in breast carcinoma.Methods By using tissue chip tech-nique creating80c ases breast carcinoma tissue chip.at the same time using the S-P immunohis-to chemical methods,the expressions of p27and cy-clinE in breast carcinoma tissue chip was studied.Results The positive rates of p27and cyclinE were38.8%and52.5%i n80cases breast carcino-ma respectively.A significant correlation was found be tween the lowexpression of p27,overexpression of cyclinE and metastasis of lymph node in breast carcinoma.A significant correlation was found be-tween the lowe xpression of p27and overexpression of cyclinE in breast carcinoma.Conclusion The expression of p27and cyclinE might be considered to be a reference indicator f or prognosis of breast carcinoma.The lowexpression of p27has an ability to effec t the overexpression of cyclinE in breast carcinoma.It is feasible to utilize ti ssue chip for a rapid,economic and accurate screening of clinical tissue specime ns on a large scale.
作者 戴艳枝 刘勇 袁晟 邓宇
机构地区 江西省人民医院
出处 《江西医药》 CAS 2003年第4期252-254,共3页 Jiangxi Medical Journal
关键词 组织芯片技术 研究 乳腺癌 P27 CYCLINE 表达 tissue chip breast carcinoma cell cy-cle immunohi stochemistry
分类号 R737.9 [医药卫生—肿瘤]
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参考文献8

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共引文献61

同被引文献26

  • 1刘勇,路名芝,袁晟.胃粘膜疾病组织芯片制作及13种细胞周期调控因子的检测[J].九江医学,2003,18(4):187-188. 被引量：1
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江西医药
2003年 第4期

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