血肌酸激酶MM亚型在AMI中的演变及其临床意义

Studies on the changes of blood CK-MM isoforms and their clinical significance in AMI

应用琼脂糖电泳法观察了21例AMI患者血浆CK-MM亚型演变。发病2～3小时,CKMM_3%和MM_3/MM_1比值即已显著上升,分别为30.6±4.8%和0.90±0.34,并于10.8±2.3小时同时达高峰(比CK-MB早12小时),峰值分别为57.9±6.4%和4.94±2.31,而后CK-MM_3迅速下降;CK-MM_1变化与其相反;发病15～24小时的主要亚型为CK-MM_2。提示观察亚型演变确实有助于AMI的早期诊断和梗塞时间与再灌注的判断。

Changes of CK-MM isoforms in 21 cases with acute myocardial infarction were observed using electrophoresis on agarose gel. CK-MM_3% and the ratio of MM_3:MM_1 elevated significantly within 2～3 hours after the onset of chest pain, the value were 30.6±4.8% and 0.90±0.34 respectively. They peaked at 10.8±2.3 hours simultaneously, which was 12 hours earlier than CK-MB. The peak value were 57.9±6.4% and 4.94±2.31 respectively. CK-MM_3 then decreased rapidly. CK-MM_1 changed oppositely to CK-MM_3. Accordingly,by studing the characterization of isoform pattern changes after AMI, one can diagnosis AMI at very early stage, predict the time of onset of necrosis, detect cronary reperfusion rapidly.