AST/ALT比值在急性心肌梗塞中的诊断价值

Evaluation of AST/ALT ratio in diagnosing acute myocardial infarction

测定72例AMI患者血清的AST,ALT和AST/ALT比值,结果表明:AST的活性高峰在36小时左右,AST/ALT的高峰值在24小时左右,稍晚于CK-MB,但比AST和LD-1/LD-2早,2～3周后逐渐恢复正常。提示:AST/ALT与其他心肌酶同时测定有助于提高MI诊断的特异性和灵敏度。

We measured serum aspartate transaminase(AST), alanine transaminase (ALT) and AST/ALT ratio in 72 patients with acute myocardial infarction. A peak of AST activity was observed in about 36 hours and AST/ALT ratio peak in about 24 hours after infarction. The peak of AST/ALT was later than CK-MB and earlier than AST and LD-1/LD-2, and decreased to normal reference limit after 2～3 weeks. Simultaneous measuring AST/ALT and other myocardial enzymes may be able to increase the sensitivity and specificity in diagnosing myocardial infarction.