2型糖尿病患者炎性细胞因子检测的意义

An analysis for Clinical Significance of Determining Inflammatory Cytokines in Patients with Type Ⅱ Diabetes Mellitus

目的 探讨炎性细胞因子IL 6、IL 8及TNF α在 2型糖尿病发病机制中的意义。方法 用双抗体夹心ELISA法检测 3 2例糖尿病患者及 2 8名正常人血清IL 6、IL 8及TNF α浓度并进行比较。结果 2型糖尿病患者血清IL 6、IL 8及TNF α水平均明显高于正常人 (p <0 0 1)。结论 患者体内高于水平的IL 6、IL 8及TNF α可能参与糖尿病的发生发展 ,3者相互作用 ,促进 2型糖尿病进展。

Objective To investigate the clinical significance of determining Inflammatory Cytokines IL 6, IL 8 and TNF α in pathogenesis of type Ⅱ diabetes mellitus (DM). Methods 32 patients with DM and 28 normal people controls were determined for the serum level of IL 6, IL 8 and TNF αwith ELISA, and were compared between two groups respectively. Results The serum level of IL 6, IL 8 and TNF αin type Ⅱ DM patients were significantly higher than those in normal people (p<0 01). Conclusions IL 6, IL 8 and TNF αmay be involved during the occurrence and development of type Ⅱ DM, the cooperation of these cytokines promotes the progress of the disease.