N-叔丁氧羰基-β-环己基天冬氨酸苄酯的合成

Study on the synthesis of benzyl N-tertbutyloxycarbonyl-β-cyclohexylaspartate

The experimental results of Benzyl Ntertbutyloxycarbonylβcyclohexylaspartate(Ⅰ)were reported in this paper.Starting from cheap and accessible Laspartic acid,the key intermediate of βcyclohexyl Ntertbutyloxycarbonylaspartate(Ⅱ)was prepared by esterification of aspartic acid via cyclohexanol catalyzed by sulfuric acid and further acylation via Boc2O.The synthesis of the title compound of(Ⅰ)was performed by benzylization of(Ⅱ)through benzyl bromide.The method is facile and the yield is higher than that in literatures.The structures of these compounds were verified by1H NMR and mp.,or by the corresponding authentic compounds.The discussion of the preparative conditions of Ⅰ and Ⅱ was also given.