慢性肝炎患者血清Ⅳ型胶原与其肝组织纤维化病理分期的相关性研究

The study on the relation of the serum IV . C and the liver tissue fibrosis stage in chronic hepatitis patients

目的 探讨慢性肝炎患者血清Ⅳ型胶原与其肝组织纤维化病理分期(S)的相关性。方法 随机选择50例慢性肝炎患者,抽静脉血检测其血清Ⅳ型胶原,肝组织活检,病理检查。结果 肝组织纤维化病理分期越高,血清Ⅳ型胶原值升高愈明显,S_1与S_2,S_2与S_3,S_3与S_4之间比较,呈现显著差异(P<0.05),肝组织纤维化病理分期与血清Ⅳ型胶原两者密切相关。结论 血清型Ⅳ胶原是观察慢性肝炎患者肝组织纤维化变化的敏感而准确的指标。

Objective To study the relation of the serum IV .C and the liver tissues fibrosis stage in patients with chronic hepatitis. Methods 50 patients with Chronic hepatitis were detected serum IV . C and. examined the liver tissue fibrosis stage with pathological methods . Results As the liver tissues fibrosis level increased, the serum IV . C increased. The serum IV . C was more correlated with the liver fibrosis stage (S) with chronic hepatitis B( P < 0.05) . Conclusion Serum IV . C is a sensitive index for the fibrosis stage of the patients with chronic hepatitis.