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遗传性非息肉病性结直肠癌的遗传及病理分析

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摘要 遗传性非息肉病性结直肠癌综合征(hereditary nonpol-yposis colorectal cancer,HNPCC)家族人群为结直肠癌最常见的高危因素。依据伴肠外肿瘤与否,该病又分为Lynch Ⅰ型(无肠外肿瘤)和Lynch Ⅱ(伴肠外肿瘤)。由于缺乏明显的可供诊断的临床病理学特点及可监测的生化指标,给早期发现及诊断本病带来困难,1990年,国际HNPCC合作组建立了该病的临床诊断标准——Amsterdam标准,内容为:(1)3个以上亲属患者有病理证实的结直肠癌,其中1人为另2人的一级亲属;(2)连续二代人患结直肠癌;(3)
作者 陈赞雄
出处 《中华消化内镜杂志》 2003年第4期269-270,共2页 Chinese Journal of Digestive Endoscopy
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参考文献7

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二级参考文献11

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