早期食管原发性腺癌初步病理分析

A Preliminary Pathologic Analysis on Early Primary Adenocarcinoma of the Esophagus

通过7例早期食管原发性腺癌手术标本系列大切片的观察,证明在早期食管癌中确有原发性腺癌存在。患者平均年龄46岁,较中晚期癌患者年轻约10岁。病理类型以浅表缺损型为主,癌灶平均长度13mm。病理特征为:(1)癌变多起始于食管固有腺腺管上段,可在相邻数个腺体内同时发生;(2)组织学上多表现为腺管癌;(3)癌灶表面和周围覆盖有受压变薄或呈增生性改变的鳞状上皮;(4)多伴有鳞癌成分。

Seven resected specimens with early primary adenocarcinoma of the esophagus were examined pathologically. The average age of the patients was 46 years and about 10 years younger than those with invasive carcinoma of this organ. Majority of the lesions showed superficial ulceration, the average length of the lesions was 13 mm. Histologic examination revealed that: 1. These cancers were commonly originated from the upper portion of the duct in submucosal gland and in the peripheral zone, the cancerous changes were commonly noticed in the neighboring several glands simultaneously. 2. The main histology was duct carcinoma of the esophageal glands. 3. The squamous epithelium overlaying and adjoining the focus became thin or proliferative. 4. Commonly accompanied by sqaumous carcinoma.