胃癌间质反应的分型及免疫组化研究

Immunohistochemistry Study on the Classification of Stromal Reaction in Gastric Carcinoma Tissue

根据癌组织中淋巴类细胞和纤维组织的反应程度把128例胃癌间质分为A、B、C三型。A型间质以所有癌细胞或癌性结构被大量的淋巴类细胞包围和边界明显为特征。C型间质主要为多量的纤维结缔组织。B型间质介于A和C型间质之间。A型间质胃癌无淋巴结转移,C型间质胃癌淋巴结转移达40.5%。UCHL,IgG,HLA—DR,AAT,ACT和含hCG,Serotonin,Gastrin等激素癌细胞的免疫组化分析认为这三型间质的形态学特征可以作为评价胃癌病人抗肿瘤免疫功能的形态学指标。

The stromal reactions of 128 cases of gastric carcinoma were classificated into 3 types of A, B, C. The type A stroma was characterized by a numerous lymphoid cells which surrounded all of the tumor cells or the carcino—structures, and by a demarcated margin. The type C stroma mainly composed of abundant fiber connective tissue, and the type B stroma intermediated between type A and C. The metastasis of lymph node did not occur in the cancer with type A stroma, but reached 40.5% in the cancer with type C stroma. The immunohistochemistry analysis on UCHL_1, IgG, HLA—DR, AAT, ACT, and the tumor cells with the hormones of hCG, Serotonin, Gastrin suggested that the morphologic characteristics of the three types of the stromal reaction might well estimate the function of immunity against tumor of the host with gastric carcinoma.