胃癌CEA免疫组化与生物学行为及预后的关系

The Correlation Between Biological Behaviour or Prognosis and Immunohistochemistry of CEA in Gastric Cancer

用PAP法对104例胃癌手术标本进行CEA反应及预后关系的研究。结果显示:胃癌组织CEA分布及含量明显异常。随癌浸润深度增加,CEA阳性率增高,脉管浸润组和淋巴结转移组CEA阳性率明显高于无脉管浸润组及无淋巴结转移组。CEA(-)组5年生存比例明显高于CEA(+)组;在浸润或转移组中,也是CEA(-)组生存比例较CEA(+)组高。提示:CEA(+)肿瘤生物学行为较恶,有扩散和转移的倾向,组织中CEA检测对确定肿瘤浸润,转移及预后有一定价值。

Gastric cancer specimens obtained from 104 patients who had undergone radical surgery were stained for carcinoembryonic antigen (CEA) by the peroxidase—antiperoxidase (PAP) method. The positivity of CEA was significantly higher in the patients with advanced stage, vascular invasion and lymph node metastasis than that in the patients without. The followup showed that the 5—year survival rate of the CEA(-) group was significantly higher than that of the CEA(+) group. Among the patients with advanced stage or lymph node metastasis, the survival rate was better in the CEA(-) group than in the CEA(+) group. The results suggest that immunostaining for CEA in gastric cancer tissue may be of value in discernment of invasion, metastasis and prognosis of gastric cancer.