摘要
目的 通过比较面神经炎患者与正常对照之间的抗水痘 带状疱疹病毒抗体滴度的差异以及面神经炎患者在不同疾病阶段的抗水痘 带状疱疹病毒抗体滴度变化 ,探讨抗水痘 带状疱疹病毒抗体与面神经炎之间的关联。方法 用酶标记葡萄球菌A蛋白 (SPA)染色法对 11例面神经炎患者及 2 6例正常人血清中抗水痘 带状疱疹病毒 (VZV)抗体进行检测 ,还对其中 6名患者进行了发病早期及 2周后的血清抗VZV抗体检测。结果 面神经炎患者组的抗VZV抗体滴度显著高于对照组 (P <0 .0 5 ) ;在 6例患者的不同疾病阶段测得的抗体滴度中 ,3例患者在发病 2周后抗体滴度比发病初期增加 4倍以上 ,1例增加 2倍 ,2例无改变。结论 抗VZV抗体滴度与面神经炎的发病相关 ,提示VZV感染可能是面神经炎的致病因素之一。
Objective Comparing the difference of the titers of anti-varicella zoster herpes virus(VZV) antibody in sera between 11 Bell's Palsy (BP) patients and 26 normal controls.Methods Using Enzyme linking staphylococcus protein A ( EL-SPA) method, we detected the titers of anti- VZV antibody in sera of 11BP patients and 26 normal controls, we also detected the titers of anti- VZV antibody in different disease stages in 6 BP patients.Results We found that the titers of anti- VZV antibody in sera of BP patients are significantly higher than those in controls ( P < 0.05). In 6 BP patients whose sera have been detected at the onset of disease and two weeks after the onset of disease, we found the titers of antibody increased 4 times or more in 2 weeks in 2 patients, the titers of antibody increased 2 times in 1 patient, and there were no titer change in the other 2 patients.Conclusion Higher titer of anti-VZV antibody is associated with BP, it suggests that the VZV infection may play a role in the pathogenicity of BP.
出处
《中国实验诊断学》
2003年第4期325-327,共3页
Chinese Journal of Laboratory Diagnosis
