三唑酮对映体的手性拆分研究

Study on the chiral separation of triadtanefon enantiomers

合成了纤维素——三(3,5-二甲基苯基氨基甲酸酯)(CDMPC),涂敷于氨基丙烷化硅胶上制备成涂敷量15%的手 性固定相。以正己烷-异丙醇为流动相,在高效液相色谱上实现了对三唑酮光学异构体的直接拆分,研究了流动相中异 丙醇的比例对分离效果的影响,优化了色谱拆分条件。

Cellulose-tris (3, 5-dimethylphenylcarbamate) (CDMPC) was synthesized and coated on aminopropyl-silica(APS) to prepare chiral stationary phase(CSP). The separation of triadimefon optical enantiorners on the CSP was studied on high-performance liquid chromatography (HPLC) using n-hexane: iso-propyl alcohol mobile phase. The influences of iso-propyl alcohol concentration in mobile phase and the column length were also investigated, and chromatographic condition was optimized.