对二甲氨基苯甲酸的合成研究

Study on the synthesis of p-(dimethylamino) benzoic acid

用硫酸二甲酯在碱性条件下将对氨基苯甲酸甲基化;在浓氨水存在下,将经甲基化的混合物在152℃水解8h;用 稀硫酸中和水解产物,得到对二甲氨基苯甲酸,产率为82.1％。

In basic medium, p-aminobenzoic acid was methylated with dimethyl sulfate. The methylated mixture was hydrolyzed at 152 'C for 8 hours in the presence of ammonia to obtain p-(dimethylamino)benzoic acid with yield of 82. 1%.