血液灌注率动态变化的光学监测

Optical Monitoring of the Dynamic Change of Blood Perfusion

研究了利用激光散斑测速原理结合CCD成像技术对大鼠肠系膜上血液灌注变化进行监测的技术。设计了用于监测大鼠肠系膜上微血管血流速度的激光散斑测量系统,通过模型实验对该测量系统的技术参数、测试精度进行分析,在此基础上,对热作用下大鼠肠系膜上微血管血流速度的变化进行动态监测,结合CCD成像技术,监测血管直径的变化,从而获得不同温度下血液灌注率的变化。

A technique of monitoring the change of blood perfusion utilizing the principle of laser speckle technique combined with CCD imaging method was studied. A laser speckle measurement system of measuring the velocities of blood flow in rat's mesentery was designed in present paper. The parameter and precision of the system was testified by a model experiment. On this basis, the dynamic changes of the velocities of the blood flow in rat's mesentery under different temperatures were measured. Meanwhile, the diameter of blood vessels was measured with CCD camera. With these measurements, changes of blood perfusion by heat were studied. The results indicated that this system and method could be used to monitor the change of blood perfusion effectively. This work provides a new method to measure thermal induced change in blood perfusion of tissue.