神经蛋白聚糖研究进展

Progress in Study on Neruocan

神经蛋白聚糖是中枢神经系统一种重要的硫酸软骨素蛋白聚糖 ,其在神经组织发育期调节细胞与细胞和细胞与基质的相互作用方面发挥了重要作用。神经蛋白聚糖在幼年期有高水平的表达 ,但在成年期很难检测到。脑损伤后 ,神经蛋白聚糖在胶质瘢痕中的表达明显增加 ,据认为可阻止轴突再生。

Neurocan is one of the major chondroitin sulfate proteoglycan (CSPG) in the central nervous system. It is a brain-specific proteoglycan, which plays an important role in modulating cell-cell and cell-matrix interactions during the development of nervous tissue. Neurocan is expressed at high level in perinatal period, but hardly detected in adult. After brain damage, the expression of neurocan obviously increases again in the glial scar. It is considered that neurocan can prevent the regeneration of axon.