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皮质酮对体外培养的海马神经元延迟整流钾电流的影响 被引量：2

EFFECT OF CORTICOSTERONE ON THE DELAYED RECTIFIED POTASSIUM CURRENTS OF CULTURED RAT HIPPOCAMPAL NEURONS IN VITRO
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摘要 目的 :探讨应激激素皮质酮对海马神经元延迟整流钾电流的影响。方法 :膜片钳全细胞记录测量原代培养大鼠海马神经元膜的钾离子电流。结果 :在皮质酮的作用下 ,海马神经元膜的钾离子电流幅度明显下调 ,激活阈电位升高。结论 Aim: The effect of stress hormone corticosterone on hippocampal neurons delayed rectified potassium currents was probed. Methods: The potassium currents of rat hippocampal neurons in primary culture were measured with patch clamp whole cell recording. Results: It showed that the amplitudes of the potassium currents in hippocampal neurons decreased. However, the threshold potential of potassium currents increased. Conclusion:It is speculated that excessive corticosterone may hurt the hippocampal neurons via its effects on the potassium currents of rat hippocampal cells.
作者 王静 马强 刘洪涛
机构地区 军事医学科学院卫生学环境医学研究所
出处 《中国应用生理学杂志》 CAS CSCD 北大核心 2003年第3期253-255,共3页 Chinese Journal of Applied Physiology
关键词 皮质酮 体外培养 海马神经元 延迟整流钾电流 corticosterone hippocampal neurons delayed rectified potassium currents
分类号 R338 [医药卫生—人体生理学] Q421 [生物学—神经生物学]
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共引文献31

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中国应用生理学杂志
2003年 第3期

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