大鼠杏仁核簇与痛觉调制的关系

THE RELATION BETWEEN AMYGDALAOID NUCLEUS IN RATS AND PAIN MODULATION

目的 :研究伤害性刺激对大鼠杏仁核簇中各亚核痛反应神经元电活动的影响。方法 :用串电脉冲刺激坐骨神经作为伤害性刺激 ,用玻璃微电极引导神经元放电。结果 :杏仁核簇中多个亚核均存在痛反应神经元。伤害性刺激使痛兴奋神经元 (PEN)诱发放电频率增加 ;使痛抑制神经元 (PIN)诱发放电频率降低 ,并出现放电频率极低现象 ;两类神经元电活动相互配合。腹腔注射吗啡 (1 0mg/kg)可以对抗伤害性刺激对痛反应神经元的作用。 结论 :杏仁核簇中的部分亚核在感受、整合和传递痛觉信息方面起一定作用 。

Aim: To research the influence of noxious stimuli on the electric activities of pain related neurons in several subnuclei of Amygdaloid Nucleus in rats. Methods: Trains of the electric impulses applied to the sciatic nerve were used as noxious stimuli. The discharges of neurons were channeled off by glass microelectrode. Results: Pain related neurons existed in several subnuclei of Amygdaloid Nucleus. When the noxious stimuli were administered the frequency of discharges of pain excited neurons (PEN) was increased while the frequency of pain inhibited neurons (PIN) was decreased to the lowest level. The electric activities of PEN and PIN were matched with each other. Intraperitoneal injection of morphine (10 mg/kg) antagonized the effects of noxious stimuli on the pain related neurons. Conclusion: Several subnuclei of Amygdaloid Nucleus play an essential role in perceiving, integrating and transmitting the pain impulses. They are a part of the central nervous system in which pain information is controlled and managed.