载脂蛋白A-Ⅰ抗动脉粥样硬化的研究进展

Advances in Apolipoprotein A-Ⅰ and It's Anti-atherosclerosis Properties

载脂蛋白A Ⅰ是HDL最主要的结构成分 ,是卵磷脂胆固醇酰基转移酶的主要激活剂。它决定了HDL的代谢和在血浆中的浓度。实验已经证明 ,载脂蛋白A Ⅰ具有抗动脉粥样硬化症的功能。在这里阐述了载脂蛋白A Ⅰ的结构和制备 ;载脂蛋白A Ⅰ和HDL的关系以及它在抗动脉粥样硬化方面的作用和可能的机理 :胆固醇的逆向转运。

Human apolipoprotein A-Ⅰ,the major protein component of high density lipoproteins and the main activator of the enzyme lecithin:cholesterol acyltransferase ,defines the structure and stability and functions of HDL.It is clearly demonstrated that high concentration of the apoA-Ⅰ not only inhibits the initiation and progression of atherosclerosis,but also makes the preexisting atherosclerotic lesions regress.This review gives an overview of the apoA-Ⅰ structure,production,relation between apoA-Ⅰ and HDL ,and several mechanisms of the apoA-I anti-atherosclerosis.These mechanisms include directing excess celluar cholesterol from the peripheral tissues to the liver in reverse cholesterol transport, inhibiting oxidative modification of LDL, and modulating inflammatory responses to favour vasoprotection.