摘要
目的 :通过研究宫颈癌组织和正常宫颈组织中差异表达的基因 ,筛选出与宫颈癌相关的基因群 ,并进一步研究其表达和初步功能。方法 :以含 2 0 4 8条人类全长基因的 c DNA基因表达谱芯片 ,检测 3例宫颈癌标本和正常宫颈标本的基因表达谱 ,计算机分析比较两种组织中差异表达的基因。 结果:3例宫颈癌差异表达基因分别有 197条、4 2 9条和 6 6 5条 ,共同差异表达的基因有 6 4条。 结论 :宫颈癌同其他肿瘤一样 ,是多种基因结构和功能改变的结果 。
Objective: To investigate the differentially expressed gene in cervical cancer and from those in normal cervical tissue and screen out some cervical cancer associated genes. Methods: Gene chips containing 2048 human genes were used to investigate the gene expression pattern of 3 samples of cervical cancer. The differentially expressed genes were selected when two patterns were compared using computer. Results: By applying this gene chip, differentially genes 197、429 and 665 were screened out respectively in 3 cervical cancer samples. 64 differentially expressed genes in all 3 cervical cancer samples were identified. Conclusion: Cervical cancer results from many changes of genes as the other malignant carcinomas. The specific cervical cancer related genes and their function need to be investigated further.
出处
《新疆医科大学学报》
CAS
2003年第4期324-326,共3页
Journal of Xinjiang Medical University
关键词
宫颈癌
基因芯片
基因表达谱
cervical cancer
gene chip
gene expression pattern