孕妇无症状HBsAg阳性胎儿宫内感染

The clinic analyses on fetus infection through uterus transmission of pregnant women with asymptomatic HBsAg positive

目的:探讨乙型肝炎病毒宫内传播的危险因素和干预措施。 方法 :对在我院分娩的无症状 HBs Ag阳性产妇抽取静脉血和其新生儿脐血 ,检测乙型肝炎病毒标志物及乙肝 DNA。对部分大三阳孕妇孕晚期注射 HBIG,观察干预效果。结果 :大三阳孕妇乙肝 DNA阳性检出率明显高于小三阳孕妇 (P <0 .0 0 1) ,其新生儿脐血 HBs Ag阳性率也明显高于小三阳孕妇 (P<0 .0 5 ) ,大三阳孕妇孕晚期注射 HBIG可降低宫内传播。 结论 :患有大三阳的母亲对胎儿威胁最大 ,应在孕前进行治疗 ,孕晚期注射

Objective: To study the risky factors of intrauterine transmission of hepatitis B virus (HBV). Methods: HBVmm and HBV DNA in the venous blood from HBsAg positive pregnant women and the umbilical blood from their newborns were studied. Results: The positive rate of HBV DNA of the pregnant women who were both positive for HBsAg and HBeAg and the positive rate of HBsAg of their newborns were significantly higher than that of other pregnant women. Conclusion: HBsAg, HBeAg positive mothers are the greatest threat to their fetus, if these women were injected with HBIG at the third trimesters, it may be good to hold up intrauterine transmission of hepatitis B virus.