骨碱性磷酸酶检测在婴幼儿佝偻病诊断中的作用

Diagnostic value of infant rickets in Hetian Prefecture with bone alkaline phosphatase

目的:探讨骨碱性磷酸酶 (BAL P)检测在婴幼儿佝偻病诊断中的价值。 方法 :选择临床资料、病史、症状、体征、X线及血生化 (钙、磷、碱性磷酸酶 )检查和小儿 BAL P测定结果完整者 4 6 0例 ,对综合资料进行分析。 结果 :和田地区婴幼儿 BAL P界值点以 >2 0 0 U/ L 为宜。佝偻病占 4 6 .3% (2 13/ 4 6 0 ) ,以活动期为主 ,佝偻病血BAL P的检出率为 87.8% ,单纯钙的检出率为 11.2 % ,磷检出率为 13.1% ,碱性磷酸酶检出率为 6 3.4 % ,与患儿临床症状、体征的符合率达 89%以上 ,与 X线检查结果的符合率达 78.9%。 结论 :BAL P测定操作简单 ,病人痛苦小 ,特异性强 ,灵敏度高 ,所用设备简单 ,能快速得出检验结果。 BAL P的高低与婴幼儿佝偻病的严重程度呈正相关 ,依靠单纯 BAL P检测结果便可诊断佝偻病 。

Objective: To evaluate the diagnostic value of bone alkaline phosphatase in infant rickets. Methods: Comprehensive data analysis were carried out in 460 cases with complete clinical history, symptoms, signs, physical examinations, X ray and blood biochemistry (calcium, phosphorus, alkaline phosphatase (ALP) and infant bone alkaline phosphatase (BALP). Results: The BALP borderline values for children in Hetian Prefecture was set at >200 units/L. Rickets account for 46.3% (213/460), and most were in active phase. The detection rate for rickets was 87.8%, higher than based alone on calcium, phosphate or ALP with detection rates of 11.2%, 13.1% and 63.4% respectively. The correlation between BALP and clinical manifestations, X ray were 89% and 78.9%, respectively. Conclusion: BALP is a very simple and convenient test, with less pain, high specificity and sensitivity. The equipment is very simple, and results can be gotten in very short time. There are positive correlations between the level of BALP and severity of rickets. The diagnosis of rickets can be made based on BALP test. The BALP method is worthy to be used in clinical practice.