小肠细菌过生长与非酒精性脂肪性肝炎的关系初步研究

A PILOT STUDY FOR THE RELATIONSHIP BETWEEN SMALL INTESTINAL BACTERIAL OVERGROWTH AND NON-ALCOHOLIC STEATOHEPATITIS

目的 :调查小肠细菌过生长在非酒精性脂肪性肝炎病人中的发生率。方法 :研究病例包括非酒精性脂肪性肝炎 39例、慢性乙型肝炎 4 7例、健康对照 2 7例。小肠细菌过生长以乳果糖H2 呼气试验诊断。结果 :小肠细菌过生长在非酒精性脂肪性肝炎的发生率为 4 5 7% ,慢性乙型肝炎为 32 5 % ,健康对照4 2 % ,前二组差异无显著性 ,但都显著高于对照组。结论 :小肠细菌过生长在非酒精性脂肪性肝炎病人有较高的发生率 ,但其因果关系尚需阐明。

Objective:To investigate the prevalence of small intestinal bacterial overgrowth in patients with non-alcoholic steatohepatitis.Methods:Thirty-nine patients with non-alcoholic steatohepatitis,47 patients with chronic hepatitis B,and 27 health control subjects were studied.Small intestinal bacterial overgrowth was assessed by lactulose hydrogen breath test.Results:Small intestinal bacterial overgrowth was present in 45.7% of patients with non-alcoholic steatohepatitis,32.5% of patients with chronic hepatitis B,and 4.2% of health control subjects.No statistical difference was found between two type of hepatitis,but both of hepatitis was higher than health control subjects.Conclusion:Patients with non-alcoholic steatohepatitis have a higher prevalence of small intestinal bacterial overgrowth.The role in the pathogenesis nedds to be clarfied.