肠道非何杰金淋巴瘤与EB病毒感染的相关性研究

TO STUDY THE INVESTIGATION OF THE EPSTEIN-BARR VIRUS WITH NON-HODGKIN'S LYMPHOMA OF THE INTESTINAL TRACT

目的 :研究肠道非何杰金淋巴瘤 (NHL)与EB病毒 (EBV)感染相关性。方法 :利用EBV寡核探针 (EBER)原位杂交法检测EB病毒。结果 :16例肠道NHL好发部位于小肠下端和结肠 ,以单发瘤结节多见 ,常伴有溃疡形成。经免疫组化证实 3例为T细胞淋巴瘤 (18.75 % ) ,13例为B细胞淋巴瘤 (81.2 5 % )。EBV EBER原位杂交 3例有阳性表达 ,均为T细胞淋巴瘤 ,阳性细胞占肿瘤细胞的 2 5 %～ 75 %。B细胞淋巴瘤未见阳性表达。结论 :肠道非何杰金淋巴瘤以B细胞淋巴瘤多发 ,并以惰性淋巴瘤为多见 ;而T细胞淋巴瘤多为侵袭性 ,且与EBV感染的相关性较高 ,与B细胞淋巴瘤无相关性。

Objective:To study the relationship of Epstein-Barr virus infection with non-Hodgkin`s lymphoma of the intestinal tract. Methods:Sixteen cases of non-Hodgkin`s lymphoma of the intestinal tract were studied.In situ hybridization was done for EBV encoding small nuclear RNA(EBER). Reaults:Sixteen cases of non-Hodgkin`s lymphoma in intestine often located at lower parts of small intestine and colon,and single mass was more often with ulcer on the surface.3/16(18.75%) cases were T cell lymphoma and 13/16(81.25%) cases were B cell lymphoma. Conclusions:The results showed that the lymphoma of the intestinal are more often as B cell type and most of them are indolent, which suggests that T cell lymphoma always means invasive. The results showed that the lymphoma has a close relllationship with EBV infection ,but Bcell type is not.