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系统性红斑狼疮患者血清Ⅳ型胶原和层粘蛋白与疾病活动程度的相关分析

The correlation between the serum collagen type Ⅳand laminin levels and disease activity in systemic lupus erythematosus
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摘要 目的 探讨系统性红斑狼疮 (SLE)患者血清中Ⅳ型胶原(Ⅳ.C)和层粘蛋白(LN)水平与疾病活动程度的相关性。方法 采用放射免疫法对42例SLE患者及20名正常对照组血清Ⅳ.C及LN含量进行了测定 ,并与作为疾病活动性指标的SLEDAI评分进行相关性分析。结果 SLE患者血清Ⅳ.C、LN水平明显高于正常对照组(P<0.01),血清Ⅳ.C、LN水平与SLEDAI评分呈显著正相关(P<0.05)。结论 Ⅳ.C、LN可能参与SLE的发病过程 ,并可作为SLE疾病活动程度的一个参考指标。 Objective To observe the relationship between the serum collagen type Ⅳ (Ⅳ.C) and laminin(LN) levels and disease activity in patients with systemic lupus erythematosus (SLE). Methods The levels of serum Ⅳ.C and LN were measured using RIA method in 42 SLE patients and 20 normal subjects.The correlation between SLE disease activity index (SLEDAI) and the serum levels of Ⅳ.C and LN was analyzed. Results The levels of serum Ⅳ.C and LN in SLE were significantly higher than those of controls.There was close correlation between the levels of serum Ⅳ.C and LN and the SLEDIA. Conclusion Ⅳ.C and LN may contribute to the pathogenesis of SLE and can be used as an index of disease activity and treatment effectiveness.
出处 《浙江医学》 CAS 2003年第8期464-465,共2页 Zhejiang Medical Journal
基金 .NULL.
关键词 系统性红斑狼疮 血清 Ⅳ型胶原 层粘蛋白 疾病活动程度 相关分析 Laminin Collagen Systemic lupus erythematosus
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参考文献7

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