海南省不同组群儿童非脊髓灰质炎肠道病毒感染的研究

Study on Non-polio Enterovirus Infection in Different Groups of Children in Hainan Province

为了研究非脊髓灰质炎 (脊灰 )肠道病毒 (NPEV)对海南省儿童健康的影响 ,对 2 37例急性弛缓性麻痹 (AFP)病例、6 91例AFP病例的接触者和 98名健康儿童感染的肠道病毒 (EV)进行分型鉴定 ,并结合流行病学资料进行分析。结果显示 ,三组儿童NPEV分离率分别为 2 6 5 8%、17 37%、2 0 4 1%。三组儿童都有埃柯 (ECHO)病毒和柯萨奇 (Coxsackie,Cox )B病毒感染 ,但ECHO病毒型别存在较大差异。AFP病例与其接触者中分离的NPEV毒株型别极少相同。 6 3例NPEV阳性的AFP病例 ,夏季发病 4 4例 ,春秋季发病 19例。除地处海南省中部山区的 3个县 (市 ,下同 )外 ,其它县都有分布。病例发病年龄 1～ 3岁的占 73 0 2 % ,男女性别比为 2∶1。79 36 %病例为不对称性麻痹。 4 76 %的NPEV阳性AFP病例在发病 6 0d后有残留麻痹 ,表明NPEV对儿童健康造成较大危害。开展儿童NPEV感染研究能为进一步巩固无脊灰成果及更加深入研究EV对人类健康的影响提供科学依据。

To study the influence of non-polio enterovirus(NPEV)infection on the health of children in Hainan Province,NPEV strains which were isolated from 237 acute flaccid paralysis(AFP)cases,691 AFP contacts and 98 healthy children were serotyped and analyzed combining with their epidemiological data.The results showed that NPEV isolation rates of three groups of children were 26.58%,17.37% and 20.41% respectively.ECHO viruses and Cox.B viruses were isolated from all three groups of children,but the types of ECHO virus among three groups had obvious difference.Very few NPEV types in AFP cases were same as that of AFP contacts.In 63 AFP cases infected with NPEV,44 cases had illness in summer and 19 cases in spring and autumn.The 63 AFP cases distributed in whole province except 3 counties(city,the same below)in the middle mountain area of Hainan Province.73.02% of 63 AFP cases were children of 1～3 years old.The sexual ratio of male to female was 2∶1.79.36% of them occurred asymmetrical paralysis.4.76% of them had residual paralysis 60 days after disease onset.So the influence of NPEV on children’s health must bring into attention.Study of NPEV infection can consolidate the situation of polio-free and provide ascientific basis to people's health.