超声引导射频消融治疗肝癌研究

A Study of Ultrasound-Guided Radiofrequeney Ablation in Treatment of Liver Cancer

目的 :探讨超声引导射频消融 (RFA)对肝癌的治疗效果。方法 :76例肝癌 1 1 2个癌灶行超声引导下RFA治疗 ,对治疗前后病灶的组织病理学改变、超声影像、螺旋CT检查、AFP变化以及生存率并发症等进行综合研究以评价疗效。结果 :RFA后再活检提示 65例 (85 .5 % )为坏死组织 ,1 1例残留癌细胞 ;1周后彩超示肿瘤血流信号明显减少或消失 ;1月后螺旋CT扫描病灶大小无明显改变 ,但CT值减低约 2 2Hu ,与治疗前相比有统计学差异 (P<0 .0 5) ,6个月、1年、2年生存率分别为 76 .3 %、67.1 %、50 .0 % ;并发症主要为肝区疼痛和低热 ,7例右例胸腔积液 ,1例胆瘘 ,1例上消化道出血。结论 :超声引导RFA为肝癌提供了有效的微创治疗手段 。

Objective To investigate the therapeutic efficacy of ultrasound-guided radio frequency abltion(RFA)in the treatment of liver carcinoma. Methods Ultrasound-guided RFA was employed to treat 76 patients with 112 tumor lesions. The changes in tumors after RFA were evaluated with histopathology color doppler ultrasonography, CT, AFP, survival rate and complications. Results After RFA necrosis was found with needle biopsy in 65 patients,retained cancer cell in 11 patients,blood stream signals obviously reduced and disappeared by color doppler ultrasonography after a week,spiral CT showed the size of tumor lesion no variability,but CT value significantly reduced about 22 Hu(P<0.05),6-month survival rate was 76.3%, 1-year 67.1%, 2-year 50.0%. Complications included pain of liver region,low fever,7 right hydrothorax,1 biliary fistula,1 upper GI bleeding. Conclusions RFA provided an effective and micro-lraant treatment of liver cancer and a better future.