传染性非典型肺炎患者体液免疫特征初步研究

An initial study on the characteristics of humoral immunity of patients with infectious atypical pneumonia

目的 :探讨传染性非典型肺炎 (severeacuterespiratorysyndrome ,SARS)患者特异性体液免疫特征。方法 :采用ELISA技术检测SARS患者血清中特异性IgG和IgM水平。 结果 :SARS患者住院期间血清特异性IgG水平持续升高 ,阳性检出率为 77 3% ;特异性IgM抗体水平住院 3周内持续升高 ,第 3周达到最高值 ,阳性检出率达 6 0 0 % ,第 4周则迅速下降。SARS患者血清IgM阳性出现时间早于IgG 1周。结论 :SARS患者血清中均存在特异性IgG抗体 ,而特异性IgM只存在 70 %～ 80 %患者血清中。

Objective:to investigate the characteristics of humoral immunity of patients with SARS Methods: The levels of the specific IgG and IgM in the serum of patients with SARS were detected by ELISA Results:The specific IgG in serum of patients with SARS increased continuously during hospitalization, The maximal rate of positive samples was 77 3%; The levels of specific IgM increased continuously in the first three weeks during in hospital, then the maximum of IgM was found in the third week, the positive rate were 60%,and decreased quickly during the forth week The occurrence of the specific positive IgM was earlier than that of IgG by one week Conclution: There were specific IgG antibody in serum of all patients with SARS and the specific IgM were only found in serum of 70%～80% patients with SARS The generation time and the basic characteristics of the specific antibody of patients with SARS were similar to that of other infectious diseases