P物质、血管活性肠肽与异常胃肠通过的关系

The relationship between substance P, vasoactive intestinal peptide and abnormal gastrointestinal transit

目的 研究P物质 (substanceP ,SP)和血管活性肠肽 (vasoactiveintestinalpeptide ,VIP)与异常胃肠通过的关系。方法 应用放射免疫方法测定了 2 2名健康志愿者、2 8名慢传输患者、2 6名快传输患者血浆及结肠组织中的SP和VIP质量浓度 ,并测定了 2 5名糖尿病患者血浆中SP及VIP质量浓度。结果 慢传输患者血浆及结肠组织SP及VIP质量浓度较健康志愿者低 ,而快传输患者血浆及结肠组织SP及VIP质量浓度较健康志愿者高 ,糖尿病患者血浆SP质量浓度较健康志愿者低。

Objective To explore the relationship between substance P (SP), vasoactive intestinal peptide (VIP) and abnormal gastrointestinal transit. Methods By radioimmunoassay, concentration of SP and VIP in plasma and the tissues of colon were determined in 22 healthy volunteers, 28 slow transit patients and 26 fast transit patients. By the same method, concentration of SP and VIP in plasma was determined in 25 patients with diabetes. Results There was a significant decrease of SP and VIP in plasma and colonic tissues in the group of slow transit patients (P<0.05) and there was a significant increase of SP and VIP in plasma and colonic tissues in the group of fast transit patients (P< 0.05). A significant decrease of SP in plasma was found in diabetes patients (P< 0.05). Conclusion The results indicate that there is some relationship between concentration of SP, VIP and abnormal gastrointestinal transit.