不孕不育与支原体感染和抗精子抗体的关系

The association of ureaplasma urealyticum and mycoplasma hominis infection with antisperm antibodies in infertile women and men

目的 探讨不孕不育与支原体感染和抗精子抗体 (ASA)之间的关系。方法 采用培养法分别对 2 4 8例不孕妇女(观察组 )和 16 7例不育男性患者 (观察组 )进行解脲支原体 (UU)和人型支原体 (MH)检测 ;采用ELISA法检测血清抗精子抗体ASA IgM和ASA IgG。同时分别选择 6 9例正常妇女和 4 3例正常男性作为对照。结果 不孕症观察组及不育症观察组UU、MH阳性检出率均明显高于对照组 (P <0 .0 5 )。不孕和不育观察组ASA阳性检出率 (2 8.6 3% ,2 0 .96 % )均显著高于对照组 (7.2 1% ,6 .98% ,P <0 .0 5 )。支原体感染阳性组ASA阳性率明显高于支原体感染阴性组(P <0 .0 2 5 )。结论 女性不孕和男性不育均与支原体感染及免疫因素有关 。

Objective To elucidate the association of ureaplasma urealyticum(UU)and mycoplasma hominis(MH)infection with antisperm antibodies (ASA) in infertile women and men. Methods UU and MH were examined respectively in the secretion by culture in 248 infertile women and 167 infertile men assigned as monitored groups,69 normal women and 43 normal men assigned as control groups. Enzyme-linked immunoassay (ELISA) was carried out to detect two isotypes of ASA, immunoglobulin M (IgM) and immunoglobulin G (IgG) in both the groups. The positive rates of UU or MH and IgM or IgG ASA were assessed in 248 infertile women and 167 infertile men. The rates were then compared with those of the control groups. Results There were significant differences in positive rate of UU,MH between monitored and control groups; the positive rates of IgM ASA in the monitored groups (28.63% and 20.96%) were significantly higher than those in the control groups (7.21% and 6.98%). For infertile women and men, the positive rate of ASA in positive UU or MH group was significantly higher than that of negative UU and MH group. Conclusion It is suggested that infertility in women and men is closely correlated with UU or MH infection and immunological factors and that ASA is correlated with UU or MH infection.