^(89)SrCl_2溶液中载体含量对其在动物体内分布的影响

The Influence of ^(89)SrCl_2 Solution With Different Amount Carrier on Biodistribution in Mice

利用89Y(n,p)89Sr反应在快中子反应堆中制得高比活度89Sr并将其溶于0.01mol/LHCl中,之后加入不同量的SrCl2配制成不同载体含量的溶液;将所得溶液注入正常小鼠体内进行体内分布及急性毒性研究。结果表明:制备的89SrCl2溶液是无菌无热原的澄明溶液,89SrCl2的核纯度>99%,90Sr的含量<1×10-4%,其它伽玛杂质<1×10-2%,89Sr的比活度>185TBq/g,满足医用要求;89SrCl2溶液特异性浓聚于骨,在24h内达到最高,在其它组织中浓聚较少;89SrCl2溶液的载体含量对其在小鼠体内的分布有明显影响,高比活度组(0.5mg/L)在骨中最高浓聚为80.2%(ID%),且7天内骨中的浓聚都显著高于其他组;载体含量对正常小白鼠有较大的毒性,其半致死剂量约为3mg,安全剂量<1mg。

The biodistribution of the 89SrCl2 solution with different amount carrier are studied. The results show that 89Sr is concentrated in bone mostly, up to maximum within 24 h, and the concentration of 89Sr in bone is affected obviously by the amount of SrCl2 in the 89SrCl2 solution. The bone concentrations of the group of high specificactivity (maximum is 80.2 ID%/g) are always higher remarkably than those of other groups (SrCl2 concentration is 0.1?0.5?2.5 and 100 g/L) in 7 days. The SrCl2 has toxicity, the half dosage caused death is about 3 mg for normal mice and the safety dosage is <1 mg.