人工诱导海南龙血竭的化学成分研究

Chemical Constituents from Artificially Induced Dragon's Blood of Dracaena cambodiana

为了解人工诱导海南龙血树(Dracaena cambodiana)所产血竭的化学成分,从其乙醇提取物中分离得到10个化合物,经波谱分析分别鉴定为socotrin-4?-ol(1)、homoisosocotrin-4?-ol(2)、(E)-3-(3,4-dihydroxybenzylidene)-7-hydroxy-chroman-4-one(3)、5-hydroxy-7-methoxy-3-(4?-hydroxybenzyl)-4-chromanone (4)、3-去氧苏木查耳酮(5)、苏木查耳酮(6)、7,4?-二羟基黄酮(7)、7,4?-二羟基-8-甲基黄酮(8)、丁香树脂醇(9)和邻苯二甲酸二(2-乙基己基)酯(10)。化合物1～10均为首次从人工诱导海南龙血树所产血竭中分离得到,其中化合物8为新天然产物,化合物3～6为首次从血竭中分离得到。化合物7和8对耐甲氧西林金黄色葡萄球菌具有生长抑制作用。

In order to understand the chemical constituents of artificially induced dragon’s blood of Dracaena cambodiana, ten compounds were isolated from the ethanol extract. On the basis of spectral data, their structures were indentified as socotrin-4?-ol(1), homoisosocotrin-4?-ol(2),(E)-3-(3,4-dihydroxybenzylidene)-7-hydroxychroman-4-one(3), 5-hydroxy-7-methoxy-3-(4?-hydroxybenzyl)-4-chromanone(4), 3-deoxysappanchalcone(5),sappanchalcone(6), 7,4?-dihydroxyflavone(7), 7,4?-dihydroxy-8-methylflavone(8), syringaresinol(9) and bis(2-ethylhexyl) phthalate(10). All compounds were isolated from artificially induced dragon’s blood of Dracaena cambodiana for the first time, compound 8 was a new natural product, compounds 3-6 were isolated from dragon’s blood for the first time. The compounds 7 and 8 had inhibitory activities against methicillin-resistant Staphylococcus aureus(MRSA).